Citrate Plasma: Essential for Clinical Chemistry and Immunochemistry Tests in the USA

Summary

• Citrate plasma may be used in exceptional circumstances for certain clinical chemistry and immunochemistry tests in a medical lab setting in the United States.
• Examples of tests that may require the use of citrate plasma include coagulation studies, fibrinogen testing, and factor assays.
• Proper handling and processing of citrate plasma samples are crucial to ensure accurate Test Results in the medical lab.

Introduction

In a medical lab setting, various tests are performed to assess a patient's health status and aid in the diagnosis and monitoring of diseases. When it comes to clinical chemistry and immunochemistry tests, the type of specimen used can greatly impact the accuracy of the results. In some cases, citrate plasma may be required for certain tests, especially in exceptional circumstances.

Examples of Clinical Chemistry and Immunochemistry Tests

Coagulation Studies

Coagulation studies are essential for evaluating a patient's ability to form blood clots. Citrate plasma is commonly used in coagulation tests, such as PT (Prothrombin Time) and aPTT (Activated Partial Thromboplastin Time), to prevent blood clotting during sample processing. This allows for accurate measurement of clotting factors and detection of abnormalities in the coagulation cascade.

Fibrinogen Testing

Fibrinogen is a critical protein involved in the formation of blood clots. Citrate plasma is often utilized in fibrinogen testing to avoid clot formation and accurately assess fibrinogen levels in the blood. Abnormal fibrinogen levels can indicate various conditions, such as bleeding disorders or thrombosis.

Factor Assays

Factor assays measure the activity levels of specific coagulation factors in the blood. Citrate plasma is necessary for factor assays to prevent clotting and ensure accurate results. Factor assays are crucial for diagnosing and monitoring coagulation disorders, such as hemophilia and von Willebrand disease.

Handling and Processing of Citrate Plasma Samples

1. Collecting samples: When collecting blood samples for citrate plasma, it is essential to use a tube containing citrate as an anticoagulant. The correct ratio of citrate to blood must be maintained to prevent clotting.
2. Centrifugation: After collection, the blood sample must be promptly centrifuged to separate the plasma from the cellular components. Improper centrifugation or inadequate mixing can lead to inaccurate Test Results.
3. Storage: Citrate plasma samples should be stored at the appropriate temperature to maintain Sample Integrity. Improper storage conditions can affect the stability of coagulation factors and compromise test accuracy.
4. Transportation: Proper handling and transportation of citrate plasma samples are crucial to prevent sample degradation. Samples should be transported in a timely manner to the lab to ensure reliable Test Results.

Conclusion

In conclusion, citrate plasma plays a critical role in certain clinical chemistry and immunochemistry tests in a medical lab setting in the United States. Tests such as coagulation studies, fibrinogen testing, and factor assays may require the use of citrate plasma in exceptional circumstances to ensure accurate results. Proper handling and processing of citrate plasma samples are essential to maintain Sample Integrity and obtain reliable test outcomes. By following established protocols for citrate plasma use, medical lab professionals can provide accurate diagnostic information to Healthcare Providers for optimal patient care.

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